Here we show that although representing a conservative substitution and predicted to be benign, the ALS associated L341V mutation of SQSTM1 is defective in recognition of LC3B. We place our observations on a firm quantitative footing by showing the L341V mutant LIR is associated with a 3 fold reduction in LC3B binding affinity and using […]

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In addition to its better known Amazon Prime Video, Amazon owns the website IMDb, which has a free streaming service. Its lineup includes decades old series like “Columbo” and “Charlie’s Angels,” along with some BBC regulars like “Midsomer Murders.” Films run the gamut. “La La Land” and “March of the Penguins” appear alongside “Groundhog Day” […]

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Getting the right style of glasses for your face shape is important. The first step is to decide just what shape your face really is. Imagine the major face shapes of a square, oval, oblong, round heart, triangle or diamond. But the other key to Warby Parker new offline strategy, as Om describes in his […]

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Broward resident Larry Steinhauser, 57, said he would campaign for a countywide pit bull ban, though Florida now prohibits laws against specific breeds. (Miami Dade’s ban was grandfathered in when the state law was passed.) A pit bull once lunged at him while he walked his dog. He also witnessed another pit bull attack, he […]

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Affleck dives into the role with serious intent, catching some terrific details that bring Christian to life, even if his various characteristics are utterly incongruous. His prickly interaction with the always superb Kendrick is enjoyable, especially their fruitless flirtation. Veterans Simmons, Lithgow, Smart and Tambor (against type as Christian’s prison mate mentor) add plenty of […]

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