Specifically for acinar to b cell reprogramming paradigms, we discuss the common view of the underlying mechanism (involving the Janus kinase STAT pathway that leads to STAT3 tyrosine phosphorylation) and present alternative interpretations that implicate STAT3 serine phosphorylation alone or serine and tyrosine phosphorylation occurring in sequential order. The implications for drug design and therapy […]

Read More »

Give Cruise this: he takes suicidal militarism and makes it affably sexy. He stares at you, murmurs, “That’s right, I am dangerous,” and zaps a grin that tells you how much fun he expects to have mowing your butt. Maverick is the master of machismo, his talent nearly matching his arrogance. South Koreanmedia speculated she […]

Read More »

Although many examples can be found in the literature that link contemporary African American music with the past, two will suffice to demonstrate the possibilities. The first pertains to the music of the folk oriented black church, the oldest institution owned by the African American community. Within that tradition, the earliest repertory of sacred song […]

Read More »

These blocked heel sandals I wore are a MUST HAVE seriously, do yourself a favor and go out and get them NOW!!! I am obsessed with these! They are comfortable and casual enough to wear walking around a big city all day and easy enough to dress up to wear them out at night. They […]

Read More »

Amitabh, normally an actor of great stature and presence, portrayed Bhakshor with a lot of love and irony, and it very apparent. He was delusional and highly dependent on his daughter yet stubborn in accepting that he needed help. He completely slapstick in all of his antics and struggles. Washington Post Cornejo Washington Post bring […]

Read More »

The selfie satisfied, Kardashian cheerleader, Olivier Rousteing, may not seem an obvious champion of the everywoman. But in his own not so subtle way, the creative director of Balmain is emerging at the forefront of a refreshing movement to reflect and cater to a wider demographic in fashion the fortysomethings. In his latest spring/summer campaign, […]

Read More »