To compute an efficient numerical solution we develop and implement a Generalized Multiscale Finite Element Method (GMsFEM) that solves nonlinear problems on a coarse grid by constructing local multiscale basis functions and treating part of the nonlinearity locally as a parametric value. After linearization with a Picard Iteration, the procedure begins with construction of multiscale […]

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Potential interventions include endothelin antagonists, neurotrophins, nitric oxide donors and phosphodiesterase 5 inhibitors, peroxisome proliferator activated receptor gamma agonists, and prostacyclin mimics and phosphodiesterase 3 inhibitors. Several drugs that have relevant properties are licensed for other disorders, offering the possibility of drug repurposing. Others are in development. It is well known for its unique style […]

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